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SPAGRM
Overview
Step 0 Calculate GRM and IBD files
Sparse GRM
Pairwise IBD
Step 1 Fit the null model
Longitudinal mean
Linear mixed-effect models
Generalized estimation equations
Within-subject variability
Longitudinal trand
Other trait types
Quantitative traits
Binary traits
Step 2 Conduct genome-wide association studies
a). Pre-estimate joint distributions of genotypes
b). Screen for marker-level association study
Strategies for improving statistical power
Frequently asked questions
Template Repository
If you have any question when using SPA
GRM
, please contact
hexu@pku.edu.cn